1,4-Dimercapto-2,3-butanediol → 2-Morpholin-4-ylethyl (6-sulphanyl-1,3-benzothiazol-2-yl)carbamate

HRID 633486ノート

反応式

HRID 633486 の反応式
[S:1]([C:4]1[CH:24]=[CH:23][C:7]2[N:8]=[C:9]([NH:11][C:12](=[O:22])[O:13][CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[S:10][C:6]=2[CH:5]=1)C#N.SCC(C(CS)O)O>P([O-])(O)(O)=O.[K+]>[SH:1][C:4]1[CH:24]=[CH:23][C:7]2[N:8]=[C:9]([NH:11][C:12](=[O:22])[O:13][CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[S:10][C:6]=2[CH:5]=1

参加物

4

反応物 2

HCID 190011,4-Dimercapto-2,3-butanediolHCID 867070062-Morpholin-4-ylethyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate

生成物 1

HCID 867070052-Morpholin-4-ylethyl (6-sulphanyl-1,3-benzothiazol-2-yl)carbamate収率 173.7%

試薬・触媒・溶媒 1

HCID 516951Monobasic potassium phosphate触媒

実験手順

The 2-morpholin-4-ylethyl (6-sulphanyl-1,3-benzothiazol-2-yl)carbamate was prepared according to the method described in Example 1b, but using 547 mg of 2-morpholin-4-ylethyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate, 12 mg of potassium dihydrogen phosphate and 1.16 g of DL-dithiothreitol. 885 mg of 2-morpholin-4-ylethyl (6-sulphanyl-1,3-benzothiazol-2-yl)carbamate are thus obtained in the form of a white solid, the characteristics of which are as follows:

後処理

  1. customThe 2-morpholin-4-ylethyl (6-sulphanyl-1,3-benzothiazol-2-yl)carbamate was prepared

出典と根拠

ORDレコード
ord-48aab0433a234f78a9ca483ca94cb326
出典データセット
uspto-grants-2016_04
特許番号
US09321777B2

反応ノート

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