化工社化工社 化学情報印刷レポート · 研究参考用
Cyclohexanemethanol → 2-(Cyclohexylmethoxy)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclohexanemethanol | HCID 7507 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Bromopyrimidine | HCID 78345 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(Cyclohexylmethoxy)pyrimidine | HCID 86694667 | — |
反応手順
NaH (1.1 equivalent) is added to an equimolar mixture of 2-bromopyrimidine and cyclohexylmethanol in THF. The reaction mixture is stirred at +60° C. for 18 hours, cooled to room temperature, partitioned between H2O and ethyl acetate. Organic portion is separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 2-(cyclohexylmethoxy)pyrimidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447078B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-08bcb063c6f745de8323dde4cf803480 |
| 出典メモ | uspto-grants-2016_09 |