Dimethylformamide → 2-(Cyclohexylmethoxy)pyrimidine-4-carbaldehyde
反応式
[CH:1]1([CH2:7][O:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CN([CH:18]=[O:19])C>C1COCC1>[CH:1]1([CH2:7][O:8][C:9]2[N:10]=[C:11]([CH:18]=[O:19])[CH:12]=[CH:13][N:14]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
4
実験手順
Knochel-Hauser reagent (2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex) is added to a mixture of 2-(cyclohexylmethoxy)pyrimidine in THF at −78° C., stirred for 15 min, then DMF is added. The reaction mixture is stirred at −30° C., quenched by aqueous NH4Cl, extracted with ethyl acetate. Combined organic layers are dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 2-(cyclohexylmethoxy)-pyrimidine-4-carbaldehyde.
後処理
- stirringThe reaction mixture is stirred at −30° C.
- customquenched by aqueous NH4Cl
- extractionextracted with ethyl acetate
- dry with materialCombined organic layers are dried over anhydrous Na2SO4
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-2973922bc5dc42598ac42412f248742d
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447078B2
反応ノート
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