Hydrogen Bromide → 2-Bromo-1-(5-methylpyridin-3-yl)ethan-1-one hydrobromide

HRID 633697ノート

反応式

HRID 633697 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[N:6][CH:7]=1.[BrH:11].BrBr.C(OCC)C>C(O)(=O)C>[BrH:11].[Br:11][CH2:9][C:8]([C:4]1[CH:5]=[N:6][CH:7]=[C:2]([CH3:1])[CH:3]=1)=[O:10]

参加物

6

反応物 4

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 24408BromineHCID 5775691-(5-Methylpyridin-3-yl)ethan-1-one

生成物 1

HCID 754812682-Bromo-1-(5-methylpyridin-3-yl)ethan-1-one hydrobromide収率 183.3%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

300 mg (2.22 mmol) of 1-(5-methylpyrid-3-yl)ethanone are dissolved in 15 mL of glacial acetic acid. 365 μl (2.22 mmol) of hydrobromic acid and 126 μl (2.44 mmol) of bromine are added to the medium. The reaction mixture is placed under magnetic stirring at room temperature for 2 hours. Ethyl ether is added to the solution until a precipitate appears. The precipitate corresponding to 2-bromo-1-(5-methylpyrid-3-yl)ethanone hydrobromide is filtered off, washed with ether and dried. The 600 mg of product obtained have the following characteristics:

後処理

  1. filtrationThe precipitate corresponding to 2-bromo-1-(5-methylpyrid-3-yl)ethanone hydrobromide is filtered off
  2. washwashed with ether
  3. customdried

出典と根拠

ORDレコード
ord-4e15c3dde3a24900aa201c09c9c8dde5
出典データセット
uspto-grants-2016_04
特許番号
US09321790B2

反応ノート

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