Hydrogen Bromide → 2-Bromo-1-(2-methylpyridin-3-yl)ethanone hydrobromide

HRID 633713ノート

反応式

HRID 633713 の反応式
[CH3:1][C:2]1[C:7]([C:8](=[O:10])[CH3:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[BrH:11].BrBr.C(OCC)C>C(O)(=O)C>[BrH:11].[Br:11][CH2:9][C:8]([C:7]1[C:2]([CH3:1])=[N:3][CH:4]=[CH:5][CH:6]=1)=[O:10]

参加物

6

反応物 4

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 24408BromineHCID 109424821-(2-Methylpyridin-3-yl)ethan-1-one

生成物 1

HCID 124162362-Bromo-1-(2-methylpyridin-3-yl)ethanone hydrobromide収率 85.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

150 mg (1.11 mmol) of 1-(2-methylpyrid-3-yl)ethanone are dissolved in 10 mL of glacial acetic acid. 365 μl (2.22 mmol) of hydrobromic acid and 63 μl (1.22 mmol) of bromine are added to the medium. The reaction mixture is placed under magnetic stirring at room temperature for 1 hour. Ethyl ether is added to the solution until a precipitate appears. The precipitate corresponding to 2-bromo-1-(2-methylpyrid-3-yl)ethanone hydrobromide is filtered off, washed with ethyl ether and dried. The 280 mg of product obtained have the following characteristics:

後処理

  1. filtrationThe precipitate corresponding to 2-bromo-1-(2-methylpyrid-3-yl)ethanone hydrobromide is filtered off
  2. washwashed with ethyl ether
  3. customdried

出典と根拠

ORDレコード
ord-e6e8eb07b46d42bea59d555283c86b8e
出典データセット
uspto-grants-2016_04
特許番号
US09321790B2

反応ノート

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