Hydrogen Bromide → 2-Bromo-1-(4-methylthiazol-5-yl)ethanone hydrobromide

HRID 633714

反応式

HRID 633714 の反応式
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[C:7](=[O:9])[CH3:8].[BrH:10].BrBr.C(OCC)C>C(O)(=O)C>[BrH:10].[Br:10][CH2:8][C:7]([C:6]1[S:5][CH:4]=[N:3][C:2]=1[CH3:1])=[O:9]

参加物

6

反応物 4

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 24408BromineHCID 1622925-Acetyl-4-methylthiazole

生成物 1

HCID 1317354732-Bromo-1-(4-methylthiazol-5-yl)ethanone hydrobromide収率 74.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

220 mg (1.56 mmol) of 1-(4-methylthiazol-5-yl)ethanone are dissolved in 10 mL of glacial acetic acid. 769 μl (4.67 mmol) of hydrobromic acid and 88 μl (1.71 mmol) of bromine are added to the medium. The reaction mixture is placed under magnetic stirring at room temperature for 2 hours. Ethyl ether is added to the solution until a precipitate appears. The precipitate corresponding to 2-bromo-1-(4-methylthiazol-5-yl)ethanone hydrobromide is filtered off, washed with ethyl ether and dried. The 350 mg of product obtained have the following characteristics:

後処理

  1. filtrationThe precipitate corresponding to 2-bromo-1-(4-methylthiazol-5-yl)ethanone hydrobromide is filtered off
  2. washwashed with ethyl ether
  3. customdried

出典と根拠

ORDレコード
ord-44d8cd39d53b4e44a88f58b454fa5c87
出典データセット
uspto-grants-2016_04
特許番号
US09321790B2

関連ノート

読み込み中…