Thionyl Chloride → 5-(chloromethyl)quinoline hydrochloride
反応式
[N:1]1[C:10]2[C:5](=[C:6]([CH2:11]O)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:15])=O>C(OCC)C>[ClH:15].[Cl:15][CH2:11][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:5]=1[CH:4]=[CH:3][CH:2]=[N:1]2参加物
4
実験手順
A solution of 190 mg (1.19 mmol) of quinolin-5-ylmethanol in 5 ml of thionyl chloride is stirred for 10 minutes at room temperature and then refluxed for 2 hours. The reaction mixture is evaporated, the solid obtained is taken up in ethyl ether and the solution is filtered, washed with ethyl ether and dried to give 255 mg of 5-chloromethylquinoline hydrochloride, corresponding to the following characteristics:
後処理
- temperaturerefluxed for 2 hours
- customThe reaction mixture is evaporated
- customthe solid obtained
- filtrationthe solution is filtered
- washwashed with ethyl ether
- customdried
出典と根拠
- ORDレコード
- ord-a9f4d3be004245d896f486396d1a8918
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321790B2
反応ノート
読み込み中…