Hydrochloric Acid → 2-(1-Pyrrolidinyl)-3-pyridinol
反応式
Br[C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1.Cl>>[N:9]1([C:2]2[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:13][CH2:12][CH2:11][CH2:10]1参加物
4
実験手順
2-bromopyridin-3-ol (200 mg, 1.15 mmol) and pyrrolidine (184 mg, 2.58 mmol) were added in a reaction tube, followed by reacting in microwave at 120° C. for 20 minutes. The reaction mixture was added with 1 M HCl solution to neutralized, and extracted with ethyl acetate and dichloromethane. The obtained organic layer was dried over magnesium sulfate, and concentrated under reduced pressure. The concentrate was purified by column chromatography to obtain 2-(pyrrolidin-1-yl)pyridin-3-ol (78 mg, 41%).
後処理
- extractionextracted with ethyl acetate and dichloromethane
- dry with materialThe obtained organic layer was dried over magnesium sulfate
- concentrationconcentrated under reduced pressure
- customThe concentrate was purified by column chromatography
出典と根拠
- ORDレコード
- ord-48275c11308c4f8f9f29ea0f02a7e2d8
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447083B2
反応ノート
読み込み中…