Trifluoroacetic acid → HCID 68328527、化合物
反応式
[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[S:15][C:14]([NH:16]CC4C=CC(OC)=CC=4)=[N:13][N:12]=3)[CH:9]=2)[N:4]([S:26]([C:29]2[CH:35]=[CH:34][C:32]([CH3:33])=[CH:31][CH:30]=2)(=[O:28])=[O:27])[CH:3]=1.C(O)(C(F)(F)F)=O>>[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[S:15][C:14]([NH2:16])=[N:13][N:12]=3)[CH:9]=2)[N:4]([S:26]([C:29]2[CH:35]=[CH:34][C:32]([CH3:33])=[CH:31][CH:30]=2)(=[O:27])=[O:28])[CH:3]=1参加物
3
実験手順
A solution of 5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine (0.50 g, 0.811 mmol) and TFA (2.0 mL, 26.9 mmol) was heated in a microwave at 100° C. for 8 min. The solvent was removed in vacuo and the residue was dissolved in DCM and washed with sat. NaHCO3. The organic layer was dried, filtered and concentrated to give the crude material. MS (ESI, pos. ion) m/z: 497 (M+1).
後処理
- customThe solvent was removed in vacuo
- dissolutionthe residue was dissolved in DCM
- washwashed with sat. NaHCO3
- customThe organic layer was dried