2-Methyl-4-methoxyaniline → N-(4-Methoxy-2-methylphenyl)-acetamide

HRID 634738

反応式

HRID 634738 の反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][O:9][C:10]1[CH:16]=[CH:15][C:13]([NH2:14])=[C:12]([CH3:17])[CH:11]=1>CC(N(C)C)=O>[CH3:8][O:9][C:10]1[CH:16]=[CH:15][C:13]([NH:14][C:1](=[O:3])[CH3:2])=[C:12]([CH3:17])[CH:11]=1

参加物

4

反応物 2

HCID 76102-Methyl-4-methoxyanilineHCID 7918Acetic Anhydride

生成物 1

HCID 95082N-(4-Methoxy-2-methylphenyl)-acetamide収率 88%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

Acetic anhydride (50 ml) was added dropwise to a solution of 4-methoxy-2-methylaniline (49.7 g, 360mmol) in DMA (200 ml) at 5° C. and the mixture stirred for 4.5 hours at ambient temperature. The solvent was removed by evaporation and the resulting solid washed with water and dried under vacuum to give N-(4-methoxy-2-methylphenyl)acetamide (57.3 g, 88%).

後処理

  1. customThe solvent was removed by evaporation
  2. washthe resulting solid washed with water
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-176f1a6305aa4a55a6e8c9853f2cfc64
出典データセット
uspto-grants-2001_02
特許番号
US06184225B2

関連ノート

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