Benzenepropanoic acid → N-(2-hydroxy-1-hydroxymethyl-ethyl)-3-phenyl-propionamide
反応式
[C:1]1([CH2:7][CH2:8][C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:12][CH:13]([CH2:16][OH:17])[CH2:14][OH:15]>>[OH:15][CH2:14][CH:13]([NH:12][C:9](=[O:11])[CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH2:16][OH:17]参加物
3
実験手順
The procedure of example 79c was followed, using 3-phenylpropionic acid and serinol. At the end of the reaction, the DMF was evaporated and CH2Cl2 was added to the residue. The white crystalline material was collected and gave pure N-(2-hydroxy-1-hydroxymethyl-ethyl)-3-phenyl-propionamide as a white solid (56%, MS: m/e=224.2 (M+H+)).
後処理
- customAt the end of the reaction
- customthe DMF was evaporated
- additionCH2Cl2 was added to the residue
- customThe white crystalline material was collected
出典と根拠
- ORDレコード
- ord-0816cec434254e5dbd036649f0c91b12
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06184236B2
反応ノート
読み込み中…