Sodium Hydroxide → 2-(4-Bromothiophen-2-yl)acetic acid
反応式
[OH-].[Na+].[Br:3][C:4]1[CH:5]=[C:6]([CH2:9][C:10]([O:12]CC)=[O:11])[S:7][CH:8]=1>>[Br:3][C:4]1[CH:5]=[C:6]([CH2:9][C:10]([OH:12])=[O:11])[S:7][CH:8]=1参加物
3
実験手順
12 ml of 10% aqueous sodium hydroxide solution was added to the 4.94 g (19.8 mmol) of ethyl 4-bromo-2-thiopheneacetate and stirring carried out for 5 hours at 90° C. The reaction liquid was then cooled and extracted with ether. The aqueous layer was neutralized with hydrochloric acid, extracted with ether, then dried and concentrated. 4.24 g (19.1 mmol, 96%) of 4-bromo-2-thiopheneacetic acid was obtained.
後処理
- customThe reaction liquid
- temperaturewas then cooled
- extractionextracted with ether
- extractionextracted with ether
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-e9db741ce31f49bcaddc0e681c0b7856
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06184245B2
反応ノート
読み込み中…