Hydrogen Bromide → N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide

HRID 634909ノート

反応式

HRID 634909 の反応式
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13]C)[CH:11]=2)[C:6]([CH3:15])=[CH:5][C:4]1([CH3:17])[CH3:16])[CH3:2].[BrH:18]>C(O)(=O)C>[BrH:18].[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([OH:13])[CH:11]=2)[C:6]([CH3:15])=[CH:5][C:4]1([CH3:16])[CH3:17])[CH3:2]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 154511021-Ethyl-7-methoxy-2,2,4-trimethyl-1,2-dihydroquinoline

生成物 1

HCID 21260952N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide収率 85%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

60 g (0.25 mol) N-ethyl-2,2,4-trimethyl-7-methoxy-1,2-dihydroquinoline was dissolved in 150 ml glacial acetic acid and 150 ml hydrobromic acid was added. The solution was refluxed for 24 h. The cooled solution was stirred in an ice/methanol bath. Subsequently the precipitate was filtered and washed several times with acetone. Colourless crystals were formed in a yield of 85%.

後処理

  1. temperatureThe solution was refluxed for 24 h
  2. filtrationSubsequently the precipitate was filtered
  3. washwashed several times with acetone
  4. customColourless crystals were formed in a yield of 85%

出典と根拠

ORDレコード
ord-0e6936646cc4469fb58c7b1693219c31
出典データセット
uspto-grants-2001_02
特許番号
US06184379B2

反応ノート

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