Hydrochloric Acid → HCID 178525233、化合物

HRID 634959ノート

反応式

HRID 634959 の反応式
C([O:3][C:4]([CH2:6][C:7]1[N:8]=[C:9]([SH:12])[S:10][CH:11]=1)=[O:5])C.[OH-].[Na+].Cl>O>[C:4]([CH2:6][C:7]1[N:8]=[C:9]([SH:12])[S:10][CH:11]=1)([OH:5])=[O:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178470768HCID 178470768、化合物

生成物 1

HCID 178525233HCID 178525233、化合物収率 87.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In 366 ml of water was suspended 185 g (0.91 mol) of 4-ethoxycarbonylmethyl-2-mercaptothiazole and 366 ml (1.84 mols) of an aqueous solution of 5 mol/l sodium hydroxide was added dropwise to the suspension. After heating the mixture for 2 hours in a steam bath with-stirring, the reaction mixture was cooled to room temperature, and 165 ml (1.90 mols) of concentrated hydrochloric acid was added dropwise to the mixture. The crystals formed were collected by filtration under a reduced pressure to provide 139.4 g (yield 87.4%) of 4-carboxymethyl-2-mercaptothiazole.

後処理

  1. additionwas added dropwise to the suspension
  2. temperatureAfter heating the mixture for 2 hours in a steam bath
  3. customThe crystals formed
  4. filtrationwere collected by filtration under a reduced pressure

出典と根拠

ORDレコード
ord-90a86f7235aa4c3d92910c4a571d06cf
出典データセット
uspto-grants-2001_02
特許番号
US06184386B2

反応ノート

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