Ethanol → 1-(2-Chloro-5-pyridylmethyl)-5-ethyl-2-nitroiminohexahydro-1,3,5-triazine

HRID 635172ノート

反応式

HRID 635172 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]([NH:12][N+:13]([O-:15])=[O:14])=[NH:11])=[CH:4][N:3]=1.[CH2:16]([NH2:18])C.[CH2:19]=O.[CH2:21](O)[CH3:22]>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:16][N:18]([CH2:21][CH3:22])[CH2:19][NH:11][C:10]2=[N:12][N+:13]([O-:15])=[O:14])=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 702EthanolHCID 712FormaldehydeHCID 6341EthylamineHCID 178512104HCID 178512104、化合物

生成物 1

HCID 1364010701-(2-Chloro-5-pyridylmethyl)-5-ethyl-2-nitroiminohexahydro-1,3,5-triazine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirring mixture of 1 g of 1-(2-chloro-5-pyridylmethyl)-3-nitroguanidine, 0.28 g of 70% ethylamine in water and 20 ml of ethanol, 0.71 g of 37% formalin solution was added dropwise with heating. The reaction mixture was heated under reflux for two hours. After being allowed to cool to room temperature, the crystals formed, which were filtrated off and recrystallized from methanol to obtain 1.15 g of the title compound. This compound is No. 2 in Table 1. m.p.: 124-125° C.

後処理

  1. additionwas added dropwise
  2. temperaturewith heating
  3. temperatureThe reaction mixture was heated
  4. temperatureunder reflux for two hours
  5. customthe crystals formed
  6. filtrationwhich were filtrated off
  7. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-9b8890ccb9ef4a74bfcb4ffe1e265c48
出典データセット
uspto-grants-2001_02
特許番号
US06187773B1

反応ノート

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