p-Aminoacetophenone → 4-(4-Acetylphenyl)amino-3-nitropyridine hydrochloride

HRID 6352

反応式

HRID 6352 の反応式
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10].[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:21])[CH3:20])=[CH:15][CH:14]=1>C(O)C>[ClH:2].[C:19]([C:16]1[CH:17]=[CH:18][C:13]([NH:12][C:3]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N+:9]([O-:11])=[O:10])=[CH:14][CH:15]=1)(=[O:21])[CH3:20]

参加物

4

反応物 2

HCID 7468p-AminoacetophenoneHCID 122442064-Chloro-3-nitropyridine hydrochloride

生成物 1

HCID 197912824-(4-Acetylphenyl)amino-3-nitropyridine hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution of 4-chloro-3-nitropyridine hydrochloride (9.75 g, 50 mmol) in ethanol (40 ml) was added to a slurry of p-aminoacetophenone (6.76 g, 50 ml) in ethanol (25 ml), and the mixture was stirred at room temperature overnight. The mixture was chilled in ice, and the yellow solid filtered off and dried in vacuo. Yield 10.1 g (69%), m.p. 197°-200° C.

後処理

  1. temperatureThe mixture was chilled in ice
  2. filtrationthe yellow solid filtered off
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-54ee79e104304afe86e6fd203bcf0aac
出典データセット
uspto-grants-1993_09
特許番号
US05248681

関連ノート

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