Thionyl Chloride → 3,3-Difluorooxolane-2,5-dione

HRID 635220ノート

反応式

HRID 635220 の反応式
[F:1][C:2]([F:10])([CH2:6][C:7]([OH:9])=[O:8])[C:3](O)=[O:4].S(Cl)(Cl)=O>C1C=CC=CC=1>[F:1][C:2]1([F:10])[CH2:6][C:7](=[O:9])[O:8][C:3]1=[O:4]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 695812,2-Difluorosuccinic acid

生成物 1

HCID 131892433,3-Difluorooxolane-2,5-dione収率 83%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 2,2-difluorosuccinic acid (1.15 g, 7.46 mmol), thionyl chloride (4 mL, 20.6 mmol) and benzene (4 mL) was heated at reflux for 2.5 h. The mixture was filtered and the filtrate was concentrated to afford the title product as an oil that crystallized on standing (838 mg, 6.16 mmol, 83% yield).

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 2.5 h
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-db005c9bb6ce4d098b8d9edbf43c09ff
出典データセット
uspto-grants-2001_02
特許番号
US06187789B1

反応ノート

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