Hydrazine hydrate (1:1) → 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acid
反応式
O.[NH2:2][NH2:3].O=[C:5]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C:12]1=O)[CH2:6][CH2:7][C:8]([OH:10])=[O:9]>C(O)C>[N:2]1[NH:3][C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[C:11]2[C:12]=1[CH2:13][CH2:14][CH2:15][CH2:16]2参加物
4
実験手順
Hydrazine hydrate (1.1 g) was added to a solution (40 ml) of 4-oxo-4-(2-oxocyclohexyl)-n-butyric acid (4.1 g) in ethanol and the mixture was refluxed for 1 hour. After the completion of the reaction, the reaction mixture was cooled and the precitated crystals were collected by filtration to give 3.9 g of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid, m.p. 135-136° C.
後処理
- temperaturethe mixture was refluxed for 1 hour
- customAfter the completion of the reaction
- temperaturethe reaction mixture was cooled
- filtrationthe precitated crystals were collected by filtration
出典と根拠
- ORDレコード
- ord-25af7388b69b40489a2e69041c91f84e
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06187774B1
反応ノート
読み込み中…