HCID 70093703、化合物 → HCID 11057421、化合物

HRID 635377ノート

反応式

HRID 635377 の反応式
[CH2:1]([O:3][C:4](=[O:25])[CH:5]=[CH:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][N:11]2[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=[O:18])=[O:17])[CH3:2]>C(OCC)(=O)C.C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][CH2:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][N:11]2[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=[O:17])=[O:18])[CH3:2]

参加物

4

反応物 1

HCID 70093703HCID 70093703、化合物

生成物 1

HCID 11057421HCID 11057421、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584252Ethanol ethylacetate溶媒

実験手順

3-[1-(Benzenesulphonyl)-1H-indol-4-yl]acrylic acid ethyl ester (2.48 g, 6.98 mmol) was hydrogenated over 10% Pd-C (500 mg) in ethyl acetate-ethanol (4:1; 75 ml), under an atmosphere of hydrogen. The catalyst was removed by filtration after 4 h, and the solvents were removed to obtain the title compound as a colourless oil which crystallised on standing (2.47 g, 100%); δH (CDCl3, 360 MHZ) 1.10 (3H, t, J=6.8 Hz), 2.57 (2H, t, J=7.5 Hz), 3.06 (2H, t, J=7.5 Hz), 4.02 (2H, q, J=7.2 Hz), 6.66 (1H, d, J=0.72 Hz), 6.98 (1H, d, J=7.5 Hz), 7.14-7.18 (1H, m), 7.34-7.38 (2H, m), 7.43-7.48 (1H, m), 7.50 (1H, d, J=3.9 Hz), 7.77-7.82 (3H, m).

後処理

  1. customThe catalyst was removed by filtration after 4 h
  2. customthe solvents were removed

出典と根拠

ORDレコード
ord-fc4049329575488ea1f0479816bef95c
出典データセット
uspto-grants-2001_02
特許番号
US06187805B1

反応ノート

読み込み中…