4-Nitrobenzoyl chloride → 5'-O-p-Nitrobenzoyl-2-N-Isobutyryldeoxyguanosine

HRID 635500ノート

反応式

HRID 635500 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:13]([NH:18][C:19]1[NH:20][C:21](=[O:36])[C:22]2[N:23]=[CH:24][N:25]([C:34]=2[N:35]=1)[C@@H:26]1[O:33][C@H:30]([CH2:31][OH:32])[C@@H:28]([OH:29])[CH2:27]1)(=[O:17])[CH:14]([CH3:16])[CH3:15]>N1C=CC=CC=1>[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([O:32][CH2:31][C@H:30]2[O:33][C@@H:26]([N:25]3[C:34]4[N:35]=[C:19]([NH:18][C:13](=[O:17])[CH:14]([CH3:15])[CH3:16])[NH:20][C:21](=[O:36])[C:22]=4[N:23]=[CH:24]3)[CH2:27][C@@H:28]2[OH:29])=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 85024-Nitrobenzoyl chlorideHCID 135407017Guanosine, 2'-deoxy-N-(2-methyl-1-oxopropyl)-

生成物 1

HCID 1371829645'-O-p-Nitrobenzoyl-2-N-Isobutyryldeoxyguanosine

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

The synthesis of this product is carried out by reacting 1.1 eq of p-nitrobenzoyl chloride with 2-N-isobutyryldeoxyguanosine for 16 hours in pyridine. After extraction with a dichloromethane/sodium bicarbonate mixture and evaporation to dryness, the product is taken up in chloroform. This product was not used because it was too insoluble.

後処理

  1. customThe synthesis of this product
  2. customfor 16 hours
  3. extractionAfter extraction
  4. customwith a dichloromethane/sodium bicarbonate mixture and evaporation to dryness

出典と根拠

ORDレコード
ord-9a69e84c0a0941aaba3f666c4f9434bd
出典データセット
uspto-grants-2001_02
特許番号
US06187914B1

反応ノート

読み込み中…