Hydrochloric Acid → 3-Chloro-4-fluorobenzoic acid

HRID 635543

反応式

HRID 635543 の反応式
C[C:2]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([Cl:11])[CH:5]=1)=[O:3].Br[O-].[Na+].S([O-])(O)=[O:16].[Na+].Cl>>[Cl:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[F:10])[C:2]([OH:3])=[O:16]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 5204223'-Chloro-4'-fluoroacetophenoneHCID 23665763Sodium BisulfiteHCID 23673712Sodium hypobromite

生成物 1

HCID 5209893-Chloro-4-fluorobenzoic acid収率 74%

実験手順

The 3-chloro-4-fluoroacetophenone is then reacted with an aqueous solution of sodium hypobromite, the aqeuous phase is treated with sodium hydrogensulfite and acidified with hydrochloric acid, and the precipitated product is recrystallized from benzene. 3-Chloro-4-fluorobenzoic acid obtained in a yield of 74%.

後処理

  1. customthe precipitated product is recrystallized from benzene

出典と根拠

ORDレコード
ord-d546c0be93c5496da77831fb43df7de5
出典データセット
uspto-grants-2001_02
特許番号
US06187952B1

関連ノート

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