Water → 1-Butyl-2-oxo-quinoline-4-carboxylic acid
反応式
[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]([O:17]CCCC)=[O:16])=[CH:7][C:6]1=[O:22])[CH2:2][CH2:3][CH3:4].[OH-].[Na+].O>O1CCOCC1>[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]([OH:17])=[O:16])=[CH:7][C:6]1=[O:22])[CH2:2][CH2:3][CH3:4]参加物
5
実験手順
A mixture of 2.04 g (6.77 mmols) of Compound b, 0.54 g of sodium hydroxide, 40 ml of water and 40 mt of dioxane was stirred at room temperature for 30 minutes. After concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluting solvent: chloroform/methanol=5/1) to give 1.44 g (yield: 87%) of Compound a.
後処理
- concentrationAfter concentration under reduced pressure
- customthe residue was purified by silica gel column chromatography (eluting solvent: chloroform/methanol=5/1)
出典と根拠
- ORDレコード
- ord-0b7ac1002a9c48df9ec7bd4af81498e1
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05248684
反応ノート
読み込み中…