Bromine → 6-Bromo-5-methyl-1H-benzo[d][1,3]oxazin-2(4H)-one

HRID 635806ノート

反応式

HRID 635806 の反応式
[CH3:1][C:2]1[C:11]2[CH2:10][O:9][C:8](=[O:12])[NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Br:13]Br>C(O)(=O)C.C(O)(C(F)(F)F)=O>[Br:13][C:3]1[CH:4]=[CH:5][C:6]2[NH:7][C:8](=[O:12])[O:9][CH2:10][C:11]=2[C:2]=1[CH3:1]

参加物

5

反応物 2

HCID 24408BromineHCID 105589525-methyl-1H-benzo[d][1,3]oxazin-2(4H)-one

生成物 1

HCID 107765166-Bromo-5-methyl-1H-benzo[d][1,3]oxazin-2(4H)-one

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒2 回HCID 6422Trifluoroacetic acid溶媒

実験手順

To a solution of 5-methyl-1,4-dihydro-benzo[d] [1,3]oxazin-2-one (0.695 g, 4.3 mmol) in acetic acid (5 mL), Br2 (0.805 g=5 mmol) solution in TFA (5 mL)+acetic acid (5 mL) was added at 10° C. Reaction mixture was stirred for 2 hours and poured over ice water. Yellow precipitate was filtered and dried at 120° C.

後処理

  1. customReaction mixture
  2. filtrationYellow precipitate was filtered
  3. customdried at 120° C.

出典と根拠

ORDレコード
ord-1631c6ae0a814f90a62a783f6a1b5dec
出典データセット
uspto-grants-2001_02
特許番号
US06191134B1

反応ノート

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