HCID 21256500、化合物 → HCID 21256457、化合物

反応式

[F:1][C:2]1[CH:15]=[CH:14][C:5]2[N:6]3[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1>CN(C=O)C.C1(C)C=CC=CC=1.O=[Mn]=O>[F:1][C:2]1[CH:15]=[CH:14][C:5]2[N:6]3[C:11]([CH:12]=[O:13])=[CH:10][N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1

参加物

実験手順

A solution of 7-Fluoro-imidazo[2,1-b]benzothiazole-3-methanol (Formula L-2) (1.0 g) in DMF (5 mL) was diluted with toluene (200 mL), the warm solution was treated with activated MnO2 (2.34 g) and azeotropically distilled for 4 hours. The cooled suspension ws filtered, the filtrate was concentrated in vacuo and the residue was diluted with ice water. Precipitated 7-Fluoro-imidazo [2,1-b]benzothiazole-3-carboxaldehyde (Formula L-3) was filtered and recrystallized from acetonitrile to yield pure 7-Fluoro-imidazo[2,1-b]benzothiazole-3-carboxaldehyde (Formula L-3) (0.89 g), m.p. 182-183°.