Chlorosuccinimide → 2-Amino-4,5-dichloro-3-nitropyridine

HRID 63587

反応式

HRID 63587 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1[N+:9]([O-:11])=[O:10].[Cl:12]N1C(=O)CCC1=O>C(#N)C>[Cl:1][C:2]1[C:7]([Cl:12])=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1[N+:9]([O-:11])=[O:10]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 40716944-Chloro-3-nitropyridin-2-amine

生成物 1

HCID 468676602-Amino-4,5-dichloro-3-nitropyridine収率 103.6%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

4-Chloro-3-nitropyridin-2-amine (0.10 g, 0.58 mmol) was dissolved in dry acetonitrile (20 mL). To the stirred solution was then added N-chlorosuccinimide (0.094 g, 0.70 mmol), and the reaction mixture was heated at 80° C. for 1 h. Volatiles were removed in vacuo and the residue purified by silica column chromatography (elution with dichloromethane) to provide the title compound as a pale brown powder (0.125 g, 85%). 1H-NMR (500 MHz, DMSO-d6) 7.35 (s, 2H, NH2), 8.36 (s, 1H, 6-H).

後処理

  1. customVolatiles were removed in vacuo
  2. customthe residue purified by silica column chromatography (elution with dichloromethane)

出典と根拠

ORDレコード
ord-5cbf9c16164641f987fd0eb820ed7ad2
出典データセット
uspto-grants-2016_09
特許番号
US09447092B2

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