化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 4-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(4-Fluoro-phenyl)-butane-1,3-dione | HCID 432655 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidine | HCID 178422714 | 46.9% |
反応手順
A mixture of 5 g of 4-fluorobenzoylacetone, 1.66 g of urea, 25 ml of ethanol, and 3.8 ml of concentrated hydrochloric acid was refluxed for 20 hours. This reaction mixture was cooled, poured into iced water, made basic with aqueous solution of potassium carbonate, and neutralized with acetic acid. The crystals that separated out were collected by filtration, washed with isopropyl ether, and dried to provide 2.65 g of pale yellow crystals. m.p. 265-268° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06191149B1 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-0c87bdaf0e5c4bbc85733afaad7cc70b |
| 出典メモ | uspto-grants-2001_02 |