m-Chloroperbenzoic acid → 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine
反応式
[Br:1][C:2]1[C:3]([NH2:11])=[N:4][C:5]([S:9][CH3:10])=[N:6][C:7]=1[Cl:8].ClC1C=CC=C(C(OO)=[O:20])C=1>C(Cl)Cl>[Br:1][C:2]1[C:3]([NH2:11])=[N:4][C:5]([S:9]([CH3:10])=[O:20])=[N:6][C:7]=1[Cl:8]参加物
4
実験手順
To a stirring solution of 5-bromo-6-chloro-2-(methylthio)pyrimidine-4-amine (intermediate 1) (52.2 mmol) in 450 ml of DCM, a solution of 12.9 g (57.4 mmol) of m-chloroperbenzoic acid (77%) (Sigma-Aldrich) in 100 ml of DCM was slowly added. The reaction mixture was stirred at room temperature for 1 hour. The formed white precipitate was filtered, washed several times with DCM and dried. 13.96 g of 5-bromo-6-chloro-2-(methylsulfinyl)pyrimidine-4-amine were obtained (98.9%).
後処理
- filtrationThe formed white precipitate was filtered
- washwashed several times with DCM
- customdried
出典と根拠
- ORDレコード
- ord-54da99abe4104ef5a9c928da98e967bc
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447095B2
反応ノート
読み込み中…