反応式
[Cl:1][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]([NH:10][CH2:11][C:12]#[CH:13])[CH:3]=1.[Br:14]N1C(=O)CCC1=O>C(Cl)Cl>[Br:14][C:3]1[C:4]([NH:10][CH2:11][C:12]#[CH:13])=[N:5][C:6]([S:8][CH3:9])=[N:7][C:2]=1[Cl:1]参加物
4
実験手順
To a stirring solution of 1.16 g (5.45 mmol) of 6-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine (intermediate 27) in 6 ml of DCM, 1.07 g (6.0 mmol) of N-bromosuccinimide were added, and stirring was continued for 4 hours at room temperature to give 5-bromo-6-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine, which was used without further purification in the next step (see intermediate 31). The completion of the reaction is monitored by thin layer chromatography.
出典と根拠
- ORDレコード
- ord-b8e265fff5ff4cec976cdc1e7c51ab0f
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447095B2
関連ノート
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