1-(4-Nitrophenyl)azetidine → Benzenamine,4-(1-azetidinyl)-

HRID 63664ノート

反応式

HRID 63664 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O>CCO.[Pd]>[N:10]1([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[CH2:11][CH2:12][CH2:13]1

参加物

4

反応物 1

HCID 5917181-(4-Nitrophenyl)azetidine

生成物 1

HCID 45078992Benzenamine,4-(1-azetidinyl)-収率 100.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

10% Pd/C (70 mg) was added to a solution of 1-(4-nitrophenyl)azetidine (0.7 g, 3.9 mmol) in EtOH (15 mL) at r.t. under N2. After stirring under 50 psi H2 overnight, the reaction mixture was filtered through Celite and concentrated to give 580 mg (99%) of the title compound as a brown oil. [M+H] Calc'd for C9H12N2, 149. Found, 149.

後処理

  1. filtrationthe reaction mixture was filtered through Celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-5ba19c232b134171a55137719f1bebac
出典データセット
uspto-grants-2016_09
特許番号
US09447046B2

反応ノート

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