Water → (2-Fluoro-4-methoxyphenyl)methanol

HRID 636749ノート

反応式

HRID 636749 の反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].[F:7][C:8]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:9]=1[C:10](OC)=[O:11].O>C1COCC1>[F:7][C:8]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:9]=1[CH2:10][OH:11]

参加物

5

反応物 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 21255685Methyl 2-fluoro-4-methoxybenzoate

生成物 1

HCID 593638(2-Fluoro-4-methoxyphenyl)methanol収率 104%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒3 回

実験手順

To a suspension of LiAlH4 (71.6 mg, 1.89 mmol) in THF (3 ml) was added dropwise a solution of methyl 2-fluoro-4-methoxybenzoate (273.3 mg, 1.48 mmol) in THF (3 ml). The mixture was stirred for 0.5 hours. To the mixture was added dropwise aqueous THF followed by water. The mixture was extracted three times with ethyl acetate and dried over MgSO4. The solvent was evaporated to give the crude title compound (240.4 mg; >99%).

後処理

  1. extractionThe mixture was extracted three times with ethyl acetate
  2. dry with materialdried over MgSO4
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-4436b359decf49398fa62d0241d72553
出典データセット
uspto-grants-2001_02
特許番号
US06194461B1

反応ノート

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