Trifluoroacetic acid → 3-Methylmorpholine-3-carboxylic acid

HRID 63685ノート

反応式

HRID 63685 の反応式
[CH3:1][C:2]1([C:15]([OH:17])=[O:16])[CH2:7][O:6][CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1([C:15]([OH:17])=[O:16])[CH2:7][O:6][CH2:5][CH2:4][NH:3]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 223091424-((Tert-butoxy)carbonyl)-3-methylmorpholine-3-carboxylic acid

生成物 1

HCID 836796483-Methylmorpholine-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-methyl-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-3-carboxylic acid (Accela ChemBio Co., Ltd., CAS: 1052680-53-1, 50 mg, 0.2.0 mmol) in DCM (1 ml) was added trifluoroacetic acid (1 mL) dropwise at room temperature. The resulting mixture was stirred at room temperature for one hour and then concentrated under the vacuum. The residue was used directly in next step without further purification,

後処理

  1. concentrationconcentrated under the vacuum
  2. customThe residue was used directly in next step without further purification

出典と根拠

ORDレコード
ord-908386cd59a441989ed9d68678a1eedf
出典データセット
uspto-grants-2016_09
特許番号
US09447086B2

反応ノート

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