Lithium Hydroxide → 3-(1H-tetrazol-1-yl)benzoic acid
反応式
[N:1]1([C:6]2[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=2)[C:9]([O:11]CC)=[O:10])[CH:5]=[N:4][N:3]=[N:2]1.[OH-].[Li+]>O1CCCC1.O>[N:1]1([C:6]2[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=2)[C:9]([OH:11])=[O:10])[CH:5]=[N:4][N:3]=[N:2]1参加物
4
実験手順
Combine ethyl 3-(1H-tetrazol-1-yl)benzoate (4.93 g, 22.6 mmol) and tetrahydrofuran/water (100 mL/25 mL). Add lithium hydroxide (1.9 g, 45.2 mmol) and heat to reflux. After 2 hours, cool to ambient temperature and extract the reaction mixture five times with a 1 M aqueous sodium hydroxide solution. Combine the aqueous layers and extracts with ethyl acetate. Acidify the aqueous layers with a 1 M aqueous hydrochloric acid solution (pH about 1) to give a solid. Collect the solid by filtration to give the title compound.
後処理
- extractionextract the reaction mixture five times with a 1 M aqueous sodium hydroxide solution
- customto give a solid
- customCollect the solid
- filtrationby filtration
出典と根拠
- ORDレコード
- ord-4b90f51fd279454db39d7c8700a3c418
- 出典データセット
- uspto-grants-2001_02
- 特許番号
- US06194406B1
反応ノート
読み込み中…