Hydrochloric Acid → 2-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid

HRID 637163ノート

反応式

HRID 637163 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([S:18]([CH3:21])(=[O:20])=[O:19])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].CO.[OH-].[Na+].Cl>ClCCl.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([S:18]([CH3:21])(=[O:20])=[O:19])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 18464688methyl 2-methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoate

生成物 1

HCID 184644382-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

Combine methyl 2-methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoate (5 mmol), methanol (10 mL), and a 1 M aqueous sodium hydroxide solution (6 mL, 6.0 mmol). After 18 hours, evaporate in vacuo to give a residue. Combine the residue, water (5 mL) and acidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (6.5 mL). Evaporate in vacuo to give a residue. Combine the residue and dichloromethane and stir. Decant and add dichloromethane and stir. Decant and combine with the first decantate. Dry over Na2SO4, filter, and concentrate in vacuo to give the title compound.

後処理

  1. customevaporate in vacuo
  2. customto give a residue
  3. customEvaporate in vacuo
  4. customto give a residue
  5. customDecant
  6. additionadd dichloromethane
  7. stirringstir
  8. customDecant
  9. dry with materialDry over Na2SO4
  10. filtrationfilter
  11. concentrationconcentrate in vacuo

出典と根拠

ORDレコード
ord-fe8157d88837429889f2a89538ee330f
出典データセット
uspto-grants-2001_02
特許番号
US06194406B1

反応ノート

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