Methanol → 5-Amino-2,3-dimethylbenzoic acid

HRID 637168ノート

反応式

HRID 637168 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[CH3:15]O>[Pd]>[CH3:15][C:11]1[C:2]([CH3:1])=[C:3]([CH:8]=[C:9]([NH2:12])[CH:10]=1)[C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 887MethanolHCID 4377758Methyl 2-methyl-5-nitrobenzoate

生成物 1

HCID 184645405-Amino-2,3-dimethylbenzoic acid

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Combine methyl 2-methyl-5-nitrobenzoate (5.32 g, 27.2 mmol) and methanol (100 mL). Add 5% palladium-on-carbon (0.27 g). Hydrogenate on a pressure apparatus at 50 psi. After 18 hours, filter through celite to remove the catalyst and evaporate the filtrate in uacuo to give methyl 2-methyl-5-aminobenzoic acid: Rf=0.34 (silica gel, ethyl acetate/hexane 1/4).

後処理

  1. filtrationfilter through celite
  2. customto remove the catalyst
  3. customevaporate the filtrate in uacuo

出典と根拠

ORDレコード
ord-003258a2b91b49f5be0fd1cddff4e5b6
出典データセット
uspto-grants-2001_02
特許番号
US06194406B1

反応ノート

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