Trifluoroacetic acid → 5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylic acid
反応式
CC([O:5][C:6]([C:8]1[NH:9][C:10](=[O:14])[NH:11][C:12]=1[CH3:13])=[O:7])(C)C.FC(F)(F)C(O)=O>>[CH3:13][C:12]1[NH:11][C:10](=[O:14])[NH:9][C:8]=1[C:6]([OH:7])=[O:5]参加物
3
実験手順
2,3-Dihydro-5-methyl-2-oxo-1H-imidazole-4-carboxylic acid 1,1-dimethylethyl ester (110.1 g, 0.556 mol) is added in portions to stirred trifluoroacetic acid (500 g). After stirring the resulting mixture at room temperature for 20 minutes the suspension is evaporated in vacuo. The solid residue is mixed with water (700 mL), the mixture filtered, and the solid residue washed with an additional portion of water (700 mL). The filter cake is then dried for 1.5 hr. at ca. 105° C., then overnight at room temperature to produce the title compound.
後処理
- customis evaporated in vacuo
- additionThe solid residue is mixed with water (700 mL)
- filtrationthe mixture filtered
- washthe solid residue washed with an additional portion of water (700 mL)
- customThe filter cake is then dried for 1.5 hr
出典と根拠
- ORDレコード
- ord-2472543bde2f4d2aa052d2a4c8ea2a7f
- 出典データセット
- uspto-grants-1985_12
- 特許番号
- US04556665
反応ノート
読み込み中…