Hydrochloric Acid → alpha-Cyclopentyl-p-hydroxybutyrophenone

HRID 637376

反応式

HRID 637376 の反応式
[CH:1]1([CH:6]([CH2:17][CH3:18])[C:7]([C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[CH:11][CH:10]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl-].[Cl-].[Cl-].[Al+3].Cl>C1C=CC=CC=1>[CH:1]1([CH:6]([CH2:17][CH3:18])[C:7]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 13175264alpha-Cyclopentyl-p-methoxybutyrophenone

生成物 1

HCID 13175265alpha-Cyclopentyl-p-hydroxybutyrophenone

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

The mixture of 4.9 g (0.02 mol) of α-cyclopentyl-p-methoxy butyrophenone, 8.0 g (0.06 mol) of aluminium trichloride and 60 ml of benzene was refluxed for 3 hours. Dilute hydrochloric acid was added, the layers separated and the organic layer washed with water. The product was extracted with 2M sodium hydroxide. The alkaline solution was made acidic. The product was extracted with methylene chloride, dried and the solvent evaporated. The residue 4.1 g (0.018 mol, 88%) was crystallized from petroleum ether. Mp. 75°-78° C.

後処理

  1. temperaturewas refluxed for 3 hours
  2. customthe layers separated
  3. washthe organic layer washed with water
  4. extractionThe product was extracted with 2M sodium hydroxide
  5. extractionThe product was extracted with methylene chloride
  6. customdried
  7. customthe solvent evaporated

出典と根拠

ORDレコード
ord-8dadc59f99e94a73b861f46460cb8c9b
出典データセット
uspto-grants-1985_12
特許番号
US04556677

関連ノート

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