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Hydrochloric Acid → alpha-Cyclopentyl-p-hydroxybutyrophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | alpha-Cyclopentyl-p-methoxybutyrophenone | HCID 13175264 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | alpha-Cyclopentyl-p-hydroxybutyrophenone | HCID 13175265 | — |
反応手順
The mixture of 4.9 g (0.02 mol) of α-cyclopentyl-p-methoxy butyrophenone, 8.0 g (0.06 mol) of aluminium trichloride and 60 ml of benzene was refluxed for 3 hours. Dilute hydrochloric acid was added, the layers separated and the organic layer washed with water. The product was extracted with 2M sodium hydroxide. The alkaline solution was made acidic. The product was extracted with methylene chloride, dried and the solvent evaporated. The residue 4.1 g (0.018 mol, 88%) was crystallized from petroleum ether. Mp. 75°-78° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04556677 |
| 出典データセット | uspto-grants-1985_12 |
| ORD ID | ord-8dadc59f99e94a73b861f46460cb8c9b |
| 出典メモ | uspto-grants-1985_12 |