Hydrochloric Acid → 2-cyclopentyl-1-[p-(N,N-dimethyl-2-aminoethoxy)phenyl]-1-(p-hydroxyphenyl)-1-butanol

HRID 637378

反応式

[CH:1]1([CH:6]([CH2:16][CH3:17])[C:7]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:18][N:19]([CH3:30])[CH2:20][CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26](Br)=[CH:25][CH:24]=1.Cl>C(O)C>[CH:1]1([CH:6]([CH2:16][CH3:17])[C:7]([C:26]2[CH:27]=[CH:28][C:23]([O:22][CH2:21][CH2:20][N:19]([CH3:30])[CH3:18])=[CH:24][CH:25]=2)([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[OH:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

実験手順

2-cyclopentyl-1-[p-(N,N-dimethyl-2-aminoethoxy)phenyl]-1-(p-hydroxyphenyl)-1-butanol, which was prepared from α-cyclopentyl-p-hydroxybutyrophenone and p-(N,N-dimethyl-2-aminoethoxy) bromobenzene according to the procedure of example 3, was dehydrated in ethanol in the presence of hydrochloric acid. The product was recrystallized from n-hexane, mp. 112°-120° C. and was found to be an 1:1 mixture of E- and Z-isomers.

後処理

customThe product was recrystallized from n-hexane, mp. 112°-120° C.
additionan 1:1 mixture of E- and Z-isomers

出典と根拠

ORDレコード: ord-4fcd5461932b4ca9abf4342ca40471a3
出典データセット: uspto-grants-1985_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04556677

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート