Dimethylcarbamoyl Chloride → N,N-Dimethyl-N'-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

反応式

Br.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[CH:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:5][CH:4]=1.[CH3:16][N:17]([CH3:21])[C:18](Cl)=[O:19]>>[CH3:16][N:17]([CH3:21])[C:18](=[O:19])[NH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]=[CH:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:7][CH:8]=1

参加物

反応物 2

HCID 6598Dimethylcarbamoyl Chloride

HCID 202086625-(4-Aminophenyl)-2(1H)-pyrazinone hydrobromide

生成物 1

HCID 13853583N,N-Dimethyl-N'-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

実験手順

5-(4-Aminophenyl)-2(1H)-pyrazinone hydrobromide is treated with dimethyl carbamoyl chloride using a procedure similar to that of Example 5 to form 5-[4-(3,3-dimethylureido)phenyl]-2(1H)-pyrazinone.

出典と根拠

ORDレコード: ord-b3da8f37854f4ccca420a187e649de79
出典データセット: uspto-grants-1985_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04556711

反応ノート

読み込み中…