Hydrochloric Acid → 3,4-dihydro-2,5-dimethyl-8-nitro-2H-1-benzopyran
反応式
Br[CH:2]([CH3:16])[CH2:3][CH2:4][C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]([N+:12]([O-:14])=[O:13])[C:6]=1[OH:15].[H-].[Na+].Cl>CS(C)=O>[CH3:16][CH:2]1[CH2:3][CH2:4][C:5]2[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]([N+:12]([O-:14])=[O:13])[C:6]=2[O:15]1参加物
5
実験手順
40.5 g of 1C was added in portions over 20 minutes to a stirred mixture of 3.4 g of sodium hydride in 300 ml of DMSO at room temperature, and the resulting mixture was stirred for 18 hours at room temperature. The mixture was poured into ice water, made slightly acidic with concentrated hydrochloric acid and filtered. The solid was dried to give 3,4-dihydro-2,5-dimethyl-8-nitro-2H-1-benzopyran (1D) as a yellow solid, m.p.: 83°-85° C.
後処理
- filtrationfiltered
- customThe solid was dried
出典と根拠
- ORDレコード
- ord-a75eae1efd71446e90da5a071a985273
- 出典データセット
- uspto-grants-1985_12
- 特許番号
- US04558040
反応ノート
読み込み中…