Chloroacetaldehyde → 4,5,6,7-Tetrahydro-1-benzofuran-4-one

HRID 637782

反応式

HRID 637782 の反応式
[C:1]1(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=[O:7])[CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:16][CH:17]=O>O>[O:7]=[C:3]1[C:2]2[CH:16]=[CH:17][O:8][C:1]=2[CH2:6][CH2:5][CH2:4]1

参加物

5

反応物 3

HCID 33ChloroacetaldehydeHCID 104341,3-CyclohexanedioneHCID 11430Potassium Carbonate

生成物 1

HCID 27335414,5,6,7-Tetrahydro-1-benzofuran-4-one収率 68%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of 1.12 g (10 mmoles) of 1,3-cyclohexanedione and 8 ml of water was added 1.38 g (10 mmoles) of potassium carbonate, and then 2 ml of 40% aqueous solution of chloroacetaldehyde was added thereto. The resulting mixture was stirred at a room temperature for 45 hours. The reaction mixture was maintained at a pH of from 7.75 to 9.50 throughout the reaction. After completing the reaction, the obtained reaction mixture was treated and analyzed in the same manner as in Example 1. It was proved from the results of the analysis that 4-oxo-4,5,6,7-tetrahydrobenzofuran was produced in a 68% yield.

後処理

  1. temperatureThe reaction mixture was maintained at a pH of from 7.75 to 9.50 throughout the reaction
  2. customthe reaction
  3. customthe obtained reaction mixture
  4. additionwas treated

出典と根拠

ORDレコード
ord-3acf00d91bd24845bfb054d1ec170446
出典データセット
uspto-grants-1985_12
特許番号
US04558143

関連ノート

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