3,4-Dichlorophenol → 2-(3,4-Dichlorophenoxy)-5-ethylthio-4-pyridinecarbonitrile

HRID 637795ノート

反応式

HRID 637795 の反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[C:5]([S:10][CH2:11][CH3:12])=[CH:4][N:3]=1.[Cl:13][C:14]1[CH:15]=[C:16]([OH:21])[CH:17]=[CH:18][C:19]=1[Cl:20].CC([O-])(C)C.[K+]>C1COCC1.CS(C)=O>[Cl:13][C:14]1[CH:15]=[C:16]([CH:17]=[CH:18][C:19]=1[Cl:20])[O:21][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[C:5]([S:10][CH2:11][CH3:12])=[CH:4][N:3]=1

参加物

6

反応物 3

HCID 72583,4-DichlorophenolHCID 135602112-Chloro-5-ethylthio-4-pyridinecarbonitrileHCID 23665647Potassium tert-butoxide

生成物 1

HCID 135602262-(3,4-Dichlorophenoxy)-5-ethylthio-4-pyridinecarbonitrile

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2-Chloro-5-ethylthio-4-pyridinecarbonitrile (4.0 g) was reacted with 3.6 g of 3,4-dichlorophenol in the presence of 2.6 g of t-BuOK in 40 ml of THF and 4 ml of DMSO. 5.5 g (84.6%) of the desired, 2-(3,4-dichlorophenoxy)-5-ethylthio-4-pyridinecarbonitrile was recovered, m.p. 68°-69° C.

後処理

  1. custom2-(3,4-dichlorophenoxy)-5-ethylthio-4-pyridinecarbonitrile was recovered

出典と根拠

ORDレコード
ord-707a4ffc5d454e00833d5210d618aff8
出典データセット
uspto-grants-1985_12
特許番号
US04558134

反応ノート

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