3,4-Dichlorophenol → 5-(3,4-Dichlorophenoxy)-2-ethylthio-4-pyridinecarbonitrile
反応式
Cl[C:2]1[C:3]([C:11]#[N:12])=[CH:4][C:5]([S:8][CH2:9][CH3:10])=[N:6][CH:7]=1.[Cl:13][C:14]1[CH:15]=[C:16]([OH:21])[CH:17]=[CH:18][C:19]=1[Cl:20].CC([O-])(C)C.[K+]>C1COCC1.CS(C)=O>[Cl:13][C:14]1[CH:15]=[C:16]([CH:17]=[CH:18][C:19]=1[Cl:20])[O:21][C:2]1[C:3]([C:11]#[N:12])=[CH:4][C:5]([S:8][CH2:9][CH3:10])=[N:6][CH:7]=1参加物
6
実験手順
5-Chloro-2-ethylthio-4-pyridinecarbonitrile (5.4 g) was mixed with 5.4 g of 3,4-dichlorophenol in the presence of 3.7 g of t-BuOK in 30 ml of THF and 30 ml of DMSO. The mixture was heated at boiling temperature for about 70 hours to give 3.2 g (36%) of the desired 5-(3,4-dichlorophenoxy)-2-ethylthio-4-pyridinecarbonitrile, m.p. 79°-81° C.
後処理
- temperatureThe mixture was heated
- customfor about 70 hours
出典と根拠
- ORDレコード
- ord-09bf00717649461e9d9fb96b8343f6d1
- 出典データセット
- uspto-grants-1985_12
- 特許番号
- US04558134
反応ノート
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