Sodium Carbonate → HCID 14099940、化合物

HRID 637816ノート

反応式

HRID 637816 の反応式
Cl.Cl[CH:3]([C:17]1[CH:18]=[CH:19][C:20]([CH3:27])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH2:4][NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH3:16].C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[CH3:16][O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][N:5]1[CH2:4][CH:3]1[C:17]1[CH:18]=[CH:19][C:20]([CH3:27])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 131062635-{1-Chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride

生成物 1

HCID 14099940HCID 14099940、化合物収率 88.3%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

In 50 ml of ethyl acetate was suspended 4.35 g (0.01 mole) of 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide hydrochloride and then 50 ml of an aqueous 10% sodium carbonate solution was added to the suspension with stirring. After further stirring overnight vigorously, the reaction mixture was recovered by decantation. After removing inorganic materials by passing the ethyl acetate layer thus recovered through a silica gel column (50 ml of silica gel), the reaction product was evaporated to dryness to provide 3.2 g (88%) of colorless resinous 5-{1-[2-(2-methoxyphenoxy)ethyl]aziridin-2-yl}-2-methylbenzenesulfonamide.

後処理

  1. stirringAfter further stirring overnight vigorously
  2. customthe reaction mixture was recovered by decantation
  3. customAfter removing inorganic materials
  4. customthus recovered through a silica gel column (50 ml of silica gel)
  5. customthe reaction product was evaporated to dryness

出典と根拠

ORDレコード
ord-70f0a2ef4b3845bcbd3794bde5e5647e
出典データセット
uspto-grants-1985_12
特許番号
US04558156

反応ノート

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