2,3-Dimethylaniline → 6-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

HRID 637938ノート

反応式

HRID 637938 の反応式
[CH2:1]([S:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[C:12]([Cl:17])[N:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C([O-])([O-])=O.[Na+].[Na+].[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=1[CH3:32]>C(O)C>[CH2:1]([S:9][C:10]1[N:11]=[C:12]([Cl:17])[CH:13]=[C:14]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=2[CH3:32])[N:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

5

反応物 3

HCID 68932,3-DimethylanilineHCID 10340Sodium CarbonateHCID 134137254,6-Dichloro-2-(octylsulfanyl)pyrimidine

生成物 1

HCID 134137406-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2-octylthio-4,6-dichloropyrimidine (3 g) in ethanol (25 ml), 2,3-xylidine (1,5 ml) and anhydrous Na2CO3 (1.25 g) are added; the mixture is refluxed for 20 hours. The residue is hot filtered and the solvent is evaporated. The residue is purified by chromathography on silica gel, yielding 1.9 g of 2-octylthio-4-chloro-6-(2,3-xylidino)-pyrimidine (III, 35).

後処理

  1. temperaturethe mixture is refluxed for 20 hours
  2. filtrationThe residue is hot filtered
  3. customthe solvent is evaporated
  4. customThe residue is purified by chromathography on silica gel

出典と根拠

ORDレコード
ord-f914c1fe74144309b8969f58fca44d9d
出典データセット
uspto-grants-1985_12
特許番号
US04559345

反応ノート

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