Trifluoroacetic acid → 6-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

HRID 637939ノート

反応式

HRID 637939 の反応式
CO[C:3]1[CH:26]=[CH:25][C:6]([CH2:7][S:8][C:9]2[N:14]=[C:13]([Cl:15])[CH:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:18]=3[CH3:24])[N:10]=2)=[CH:5][CH:4]=1.F[C:28](F)(F)C(O)=O>>[CH2:7]([S:8][C:9]1[N:14]=[C:13]([Cl:15])[CH:12]=[C:11]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:18]=2[CH3:24])[N:10]=1)[CH2:6][CH2:25][CH2:26][CH2:3][CH2:4][CH2:5][CH3:28]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 134137342-p-Methoxybenzylthio-4-chloro-6-(2,3-xylidino)-pyrimidine

生成物 1

HCID 134137406-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

実験手順

To a suspension of 2-p-methoxybenzylthio-4-chloro-6-(2,3-xylidino)-pyrimidine (8 g; see example 5) in trifluoroacetic acid (80 ml) anisole (2,7 ml) is added and the mixture is refluxed for 50'. After cooling, the trifluoroacetic acid is evaporated. The residue is dissolved in ethyl ether and the separated solid is filtered, washed with ethyl ether, then with water to neutrality, with cool acetone and again with ethyl ether. 5 G of the desired product (III, 33) are obtained.

後処理

  1. additionis added
  2. temperaturethe mixture is refluxed for 50'
  3. temperatureAfter cooling
  4. customthe trifluoroacetic acid is evaporated
  5. dissolutionThe residue is dissolved in ethyl ether
  6. filtrationthe separated solid is filtered
  7. washwashed with ethyl ether

出典と根拠

ORDレコード
ord-8319fd7926ec4142b96f85f1bcc80915
出典データセット
uspto-grants-1985_12
特許番号
US04559345

反応ノート

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