5-Aminoisoquinoline → 1-Cyclopentyl-3-(isoquinolin-5-yl)urea

HRID 63827

反応式

HRID 63827 の反応式
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.CCN(C(C)C)C(C)C.[N:21]([CH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1)=[C:22]=[O:23]>C(Cl)Cl>[CH:24]1([NH:21][C:22]([NH:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][N:2]=[CH:1]3)=[O:23])[CH2:28][CH2:27][CH2:26][CH2:25]1

参加物

5

反応物 3

HCID 707665-AminoisoquinolineHCID 81531DiisopropylethylamineHCID 643500Cyclopentyl Isocyanate

生成物 1

HCID 471931071-Cyclopentyl-3-(isoquinolin-5-yl)urea

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To isoquinolin-5-amine (0.23 g, 1.595 mmol) in DCM (5 mL) was added DIEA (0.557 mL, 3.19 mmol) and isocyanatocyclopentane (0.180 mL, 1.595 mmol). After 24 h, the reaction was quenched with H2O (15 mL) and extracted with EtOAc (3×30 mL). The combined organic layers were washed with brine (10 mL) and dried (MgSO4). The impure yellow solid was collected and was carried onto the next step. MS (ESI) m/z: 256 (M+H)+.

後処理

  1. customthe reaction was quenched with H2O (15 mL)
  2. extractionextracted with EtOAc (3×30 mL)
  3. washThe combined organic layers were washed with brine (10 mL)
  4. dry with materialdried (MgSO4)
  5. customThe impure yellow solid was collected

出典と根拠

ORDレコード
ord-1795619309db438199d1eeb3372fdb91
出典データセット
uspto-grants-2016_09
特許番号
US09447110B2

関連ノート

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