Thionyl Chloride → 6-Chloro-2-(4-methylphenyl)-4-quinolinecarbonyl chloride

HRID 638286ノート

反応式

HRID 638286 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1)[CH:6]=[C:5]2[C:19]([OH:21])=O.S(Cl)([Cl:24])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1)[CH:6]=[C:5]2[C:19]([Cl:24])=[O:21]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 11330936-chloro-2-(4-methylphenyl)quinoline-4-carboxylic acid

生成物 1

HCID 202536626-Chloro-2-(4-methylphenyl)-4-quinolinecarbonyl chloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 28.4 g of 6-chloro-2-(4-methylphenyl)-4-quinolinecarboxylic acid, 100 ml of thionyl chloride, and 200 ml of toluene was stirred and heated under reflux for 1.5 hr. The reaction mixture was then concentrated in vacuo, the residue was treated with more toluene, and the mixture again concentrated in vacuo. The residue was recrystallized from 300 ml of heptane to give 17.7 g of the above-named compound as a yellow solid.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 1.5 hr
  3. concentrationThe reaction mixture was then concentrated in vacuo
  4. additionthe residue was treated with more toluene
  5. concentrationthe mixture again concentrated in vacuo
  6. customThe residue was recrystallized from 300 ml of heptane

出典と根拠

ORDレコード
ord-42a32148d24b4982b783a122129ca0c1
出典データセット
uspto-grants-1985_12
特許番号
US04560692

反応ノート

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