Hydrazine hydrate (1:1) → 1-Amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one

HRID 63833ノート

反応式

HRID 63833 の反応式
Cl[CH2:2][CH2:3][N:4]([CH2:14][C:15]([F:18])([F:17])[F:16])[C:5](=O)[O:6]C1C=CC=CC=1.[NH2:19][NH2:20].O>C(O)C>[NH2:19][N:20]1[CH2:2][CH2:3][N:4]([CH2:14][C:15]([F:18])([F:17])[F:16])[C:5]1=[O:6]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 118047012Phenyl N-(2-chloroethyl)-N-(2,2,2-trifluoroethyl)carbamate

生成物 1

HCID 867756191-Amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Into a 250-mL round-bottom flask, was placed a solution of phenyl N-(2-chloroethyl)-N-(2,2,2-trifluoroethyl)carbamate (5.6 g, 19.88 mmol, 1.00 equiv) in ethanol (100 mL), NH2NH2.H2O (10 mL, 80%). The resulting solution was heated to reflux overnight in an oil bath. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate (1:1). This resulted in 0.8 g (22%) of 1-amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one as colorless oil. (ES, m/z): 184 [M+H]+

後処理

  1. customInto a 250-mL round-bottom flask, was placed
  2. temperatureThe resulting solution was heated
  3. temperatureto reflux overnight in an oil bath
  4. concentrationThe resulting mixture was concentrated under vacuum
  5. customThis resulted in 0.8 g (22%) of 1-amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one as colorless oil

出典と根拠

ORDレコード
ord-bde14ba1044f4cf1886949c643ee5a50
出典データセット
uspto-grants-2016_09
特許番号
US09447084B2

反応ノート

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