Hydrazine hydrate (1:1) → 1-Amino-3-(2,2,2-trifluoroethyl)-1,3-diazinan-2-one
反応式
Cl[CH2:2][CH2:3][CH2:4][N:5]([CH2:15][C:16]([F:19])([F:18])[F:17])[C:6](=O)[O:7]C1C=CC=CC=1.[NH2:20][NH2:21].O>C(O)C>[NH2:20][N:21]1[CH2:2][CH2:3][CH2:4][N:5]([CH2:15][C:16]([F:19])([F:18])[F:17])[C:6]1=[O:7]参加物
4
反応条件
- 温度
- 90 °C
実験手順
Into a 100-mL round-bottom flask, was placed phenyl N-(3-chloropropyl)-N-(2,2,2-trifluoroethyl)carbamate (1.4 g, 4.73 mmol, 1.00 equiv), NH2NH2.H2O (6 mL), ethanol (40 mL). The resulting solution was stirred for 5 h at 90° C. in an oil bath. The resulting mixture was concentrated under vacuum. The resulting solution was diluted with 50 mL of H2O. The resulting solution was extracted with 3×30 mL of ethyl acetate and the organic layers combined. The resulting mixture was washed with 2×30 mL of brine. The mixture was dried over anhydrous sodium sulfate. The resulting mixture was concentrated under vacuum. This resulted in 200 mg (crude) of 1-amino-3-(2,2,2-trifluoroethyl)-1,3-diazinan-2-one as a light yellow solid.